Biochemical complexity drives log‐normal variation in genetic expression
نویسندگان
چکیده
منابع مشابه
Biochemical Complexity Drives Log - Normal Variation in Genetic Expression
Cells exhibit a high degree of variation in levels of gene expression, even within otherwise homogeneous populations. The standard model to describe this variation centers on a gamma distribution driven by stochastic bursts of translation. Stochastic bursting, however, cannot account for the well-established behavior of strong transcriptional repressors. Instead, it can be shown the very comple...
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Traditional statistical estimates Ŝ(x1, . . . , xn) for different statistical characteristics S (such as mean, variance, etc.) implicitly assume that we know the sample values x1, . . . , xn exactly. In practice, the sample values x̃i come from measurements and are, therefore, in general, different from the actual (unknown) values xi of the corresponding quantities. Sometimes, we know the probab...
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BACKGROUND Identifying variants that regulate gene expression and delineating their genetic architecture is a critical next step in our endeavors to better understand the genetic etiology of complex diseases. The appropriate genomic tools are in place, and preliminary analytic strategies have been developed. METHODS Here we used Genetic Analysis Workshop (GAW) 19 data to investigate the genet...
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ژورنال
عنوان ژورنال: Engineering Biology
سال: 2017
ISSN: 2398-6182,2398-6182
DOI: 10.1049/enb.2017.0004